Short Communication Inhibition of phagocytosis reduced the classical activation of BV2 microglia induced by amyloidogenic fragments of beta-amyloid and prion proteins
نویسندگان
چکیده
Fushan Shi1,2, Lifeng Yang1, Jihong Wang1, Mohammed Kouadir1, Yang Yang1, Yongyao Fu1, Xiangmei Zhou1, Xiaomin Yin1, and Deming Zhao1* State Key Laboratories for Agrobiotechnology, Key Lab of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310029, China *Correspondence address. Tel: þ86-10-62732980; Fax: þ86-10-62732987; E-mail: [email protected]
منابع مشابه
Inhibition of phagocytosis reduced the classical activation of BV2 microglia induced by amyloidogenic fragments of beta-amyloid and prion proteins.
The inflammatory responses in Alzheimer's disease and prion diseases are dominated by microglia activation. Three different phenotypes of microglial activation, namely classical activation, alternative activation, and acquired deactivation, have been described. In this study, we investigated the effect of amyloidogenic fragments of amyloid β and prion proteins (Aβ1-42 and PrP106-126) on various...
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